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KMID : 0363320110320020217
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Journal of Korean Oriental Internal Medicine
2011 Volume.32 No. 2 p.217 ~ p.231
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Effects of Saengmaekcheongpye-eum on LPS-Induced COPD Model
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Kim Yong
Yang Soo-Young
Kim Min-Hee
Namgung Uk
Park Yang-Chun
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Abstract
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Objectives: This study aimed to evaluate the effects of Saengmaekcheongpye-eum (SCE) on a LPS-induced COPD (chronic obstructive pulmonary disease) model.
Materials and Methods: The extract of SCE was treated to A549 cells and and LPS-induced COPD mouse model. Then, various parameters such as cell-based cyto-protective activity and histopathological finding were analyzed.
Results: SCE showed a protective effect on LPS-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, elastin contents, protein levels of cyclin B1, Cdc2, and phospho-Erk1/2, and gene expression of TNF- and IL- in A549 cells. SCE treatment also revealed a protective effect on LPS-induced lung injury in COPD mouse model. This effect was evidenced via histopathological findings including immunofluorescence stains against elastin and caspase 3, and protein levels of cyclin B1, Cdc2, and Erk1/2 in lung tissue.
Conclusions : These data suggest that SCE has pharmaceutical properties on lung injury. This study thus provides scientific evidence for the efficacy of SCE for clinical application to patients with COPD.
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KEYWORD
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Saengmaekcheongpye-eum, chronic obstructive pulmonary disease, emphysema, A549 cell
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